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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9db6a139e6d289119da79cb2e5d4d43eccf34a0c4ea7fde31241b72cc1f74d18' 
  AND token = 'OwlxVs4dyt3Pfh/KO7EDOYXVnhfBNzpufdeDAn+kJd8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}