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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a5c05b323065953a1b1d3f014726cf07a80380b363ed5bfbd9c17686ba45a395' 
  AND token = '34JP+gwlpymbSUL7IYUBiZEfm7mpJg4Lf0VNFo8nd5M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}