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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '290aac345510ca41b99699fc1e2a019d859c48a07fd633335d502c83335423f2' 
  AND token = 'l6ThzssfM+nuLZcq7SFEZ8LmoTSV81yWaQKZaz1QPIw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}