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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a64ee8d3ee8fc48718525e30e23390eb2d7272ecb1455efba187fb375287d627' 
  AND token = 'S45p93issdQWbT50fabCw3Pk4z5Bl0rkI8FgWI2v34A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}