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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4c22d5eb2253f4318459513dd8ac04a9460ed6bfa0e4227425375436080a6165' 
  AND token = 'MteT5IJ7uRf392fGFyS70tspVSSCXGo5ylCz4hvVyjA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}