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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'bd5c4df6a73f3bb2de68d50455ee64f02b9741e9f339f537be6e01053991f6c0' 
  AND token = 'DRI46XNDk9UWvdlhrd59fBg3S0lO2oYrj9Ari5zrlSo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}