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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2aa1ab5ffc88becaed6eae4b39fdd303afd72a80dcf8f6fd3f642cf342586525' 
  AND token = 'JCUTwQFfDcyBuTNu5stWLYlQDEY7JqICaFSEuSTbk60=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}