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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65b242df04af114d71889ed6995356036b872ac642404652f10f9d90895d5490' 
  AND token = 'C5pEXpYWaRHK3YnvsRSFt/xnmc3GUk5W9fzqU6TW6FQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}