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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8606a388ee0508416089e76fee81633a904d8b172a1ef69812c72e016af2c607' 
  AND token = 'nYr9sJ8hs8TV2wpGxRRcSd4tS68w9OmBw0QPanbh+RQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}