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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e21ce06908458976f576f36277cab68d5fcdcd9fed50c37554c086b5b95f5c69' 
  AND token = 'FkYuA6JRWuUa3T1D2M++hvtinV2DajEezXW1j5/lYO4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}