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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8b80f46670339dd9432998f662c2ab396e6f2f9b4359167fea744184a2a1b6f8' 
  AND token = 'witanUbWRKQ5qbYiSttxEOgbHc+gaeID/Qoyr+PedPc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}