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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '18a5b65580974500c11f00b9f6e078f0160b3d9bf9d3d726d48d6dc7fff83b87' 
  AND token = 'f/EiMQJq21XXgUQ2mNQm4KNwpZ9bZYr0Mn1EnNQIT+A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}