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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6ed0f328c160cb5ca35451b297345a3644daf2581d8b7d96d31e716c3bcc8403' 
  AND token = '/hbII6yFWs0kDo24YWqEgj4BDL3sMyKVy0dD71RdK9k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}