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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22e71bca611023b2686850f6534164d5a6bd78ccd41af2d9c0df91ec6072e9c0' 
  AND token = 'TUBNtY5WuIlJZkTWZVp+spjfEf1e55XsHIraXY7UjiE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}