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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e21116971c4ed9b2581fd653e67a49044e8c3d368cc3b50f546cef6e34d5a4d5' 
  AND token = 'I1RjPGfJzuRRbVBrn8M0qbciYAI8cT1ibUyy0MHTTsg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}