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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '347b49812a88ed8d22c022486a2bcc5ce166a6a2dde7a83d4a2d422ec12593c3' 
  AND token = 'Gw66bcCuhWRdl8os4aiZnlB3rfvqVVvCvzVex8cICj4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}