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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '539a227f7e614f972f59e9a4e45b23b822669a1a07aa99e1d0e05611af8fd901' 
  AND token = 'X+VEx5pbPrqVA+pprf5PDsTjaDHcb9oGWYR7UZQNesU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}