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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '100465e5376c5d2f0fe4d289062001cc12adba3b30c72edf2c8c38c61dda2433' 
  AND token = 'FXkW1bMgtx+Fcl6CRFScFubtb+M0Sbah4Wix9v54bcE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}