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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '778964ebdd1298d1f5ab26921f366b8f0de6e085052e8356f2b4a35cee1f1dc5' 
  AND token = 'dE0d/lpbxgHnRQ5v4LxJT5jMje1+SzRk5tL9SFZOtsI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}