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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ec864e0b016f841ccd2447ecfa83fc878ce06564590e706d802b35f758908c48' 
  AND token = 'rGwlu9ccyB+aIGKowmXl+mDvkLnCz8tyFpvdkZ7T/W0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}