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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '05f0250f083fa864bce339adc5d1561ad50c747753108a477a1899a10b9d138f' 
  AND token = 'dQnInnQShJHHP2waREGYXn3HK8+/HmFbJVWNG69Y76I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}