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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e518ec8742a22953b24b44b1833dacb6e46ed04b2096324de36557ff04c27287' 
  AND token = 'V8jB7FCJdIwoEsk+K1N0r8LHzGPX49s5okWycdZ8gPU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}