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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f0278d5b9494ade7e38eafc61b320cf9e31d8686d647e678762c7c1b7151fbd4' 
  AND token = 'YNdqtSaQS8a+B0yF5q4/do0yo9iy4TLpsZdXtfhN4VU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}