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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '356811b358041a64a20b8d4ebaaf18c015bf12cefd2f50d56b2e2b280ee54193' 
  AND token = '+x4ACwrquFP5clVUC+6V1pndOJAd3lChgzlNAiX0BbY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00047

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}