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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0eb157eeebfefc5e799d4d99d6f1e0df0074d64df405859109b75bd381b53957' 
  AND token = '48RMLSuqdW71x7GKIr0KJLjJPs0EWiGPhmpDGQCF0po=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}