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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8d5bd43bb1c0387ef4b32e43b91fc5d7c01c5b4a22034bce21cee5b24a227894' 
  AND token = '2XjM6Rcd0C1zou9lJ1mrcAsmXiIgthvKqZK6FfQaX+w=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}