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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e710da379b5287afdd2ca3220f7a291f2c0e9f76eb0ca2fd83c1829e0675baba' 
  AND token = 'MzAp1dXmqikUwW2wxZpfJSpR2TjFHTsSKco0T66aPY8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}