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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4d00910326e7a5dc63049dd1c47206494bffb47f932cb0cfaaae7c30ede86221' 
  AND token = 'XanDoIq4K+xt46nc0SgdkwjUoqVKee1L7MOfCEy7N0o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}