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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43f006c1cbc94d857d7f6dc6bf111b58beb13876d70e3ff2ca1d8c0de9e08848' 
  AND token = '5ZGVZUQ/DRB6xGVxyvj5Y080QoJvMPOepGwp6V8JrRQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}