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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '01a8c0242abcab3145111a461536a428fe6dc66de9f64cb41f76d79e7f959f1d' 
  AND token = 'hBw53GC8V+plnnEpHRVtyIRtk5vprDoFWGt3Ro6Oftw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}