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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ec0b248946418509703ece633365901381a07d532f42c7accee6e60f6c6aeda1' 
  AND token = 'Tk2o0q91OfHU+QSk4HR2dsdiGRMyRUT7jvWwisQv6Ow=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}