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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e43a71bb45f128d1731f33315e23254e9459b2e9456377b7fec580bb9c48feb0' 
  AND token = '2puVzkcNWvHdWIUxwzH4IxcocWnyJMla5k5ngOpvAZw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}