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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f80e113f83dd6de094142c6d00a00025f6b1705b878e8aa713b94a4037c4ad48' 
  AND token = 'vlQGxVeIOfk6YrMmiMhpqxepwXmUWKYt+bEbiwRldCw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}