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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cdf2f303c49de8fcd7878ac24792943b4857200f9f0952fd2e21e86047826a32' 
  AND token = '7iKWb6gEUsvpNkiyvUlH0JbaVCAkARQZgpayQztQByA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}