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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'da43b252607631af9651579c99eb69fd2daed63ee79ae60b1a9339e0dc14a931' 
  AND token = 'cgwSL+wQWNvdCZ/hvlSMdHYns2oOum6yRHL7GCF4Tg0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}