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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ed16ad201b915eac816529e2a877aa9bd22a2f35a25ddbe53d2c68807486fd7c' 
  AND token = 'Q0Gsj1PoonXoDS7FUNgfR8MEdr+awnlR3BKtGkZ0BPc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}