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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2280ce10b7d205a3aca184b86da38f004534dec6049d1fb9a45af8b341ccf9e0' 
  AND token = 'V4Qa5J5J75Aij7mjrhtGbA1a1dcusLbHdzwcbznv0/4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}