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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '133ee9037d3c36651a2cb2b3165bc5a3bea84b66f3a4a60846ee37803a1c867b' 
  AND token = 'Ic38cyQVVglsZ3XylpqNAY8mqNccCmiI+ixX9Fl0PsY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}