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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '727de9ac325ae2541f36d17443810f477f0252b9fd731c0131f5234ccedf0a20' 
  AND token = 'FZZcxf/CTGlb+M00wLA7mo0Xi21N0WByMkH0Pdp6FC0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}