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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '01aac4fa5e566206125246b154d4112435aef5e280a088f964c97d756a37f19a' 
  AND token = 'qq0Yv21G8Q+3KYbPBfZsv1HLtH6sD9f3srIlkByw2dQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}