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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '045a6b7b989428840e9ae62d880209d8d4094b4ce24b8642f79170696d89090f' 
  AND token = 'VM4yo7oHzb0sYj6bWhg73L+RHZPtCfp+vr0smfZzkcA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}