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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd8ede3ab94ede3f1288dcb78b75b564133b229454886c4f5b02f4ea303853c1a' 
  AND token = 'ZtJ+K5sgAJHtF8xbDW0jHjlW78Ci7PVYWMralS4mHyU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}