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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b4c2fee06be6fb37f4bb70540e48455a7b881d37655fbb3ff9f0b8b306786a45' 
  AND token = 'gOVhQuxt0x8JGN9kRvbLc72ePNgEdWR+dFXEmf+sdPY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}