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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4b5afd43ecdf3fe7a879a5e4a2f84437828a47018566c224c3df6f39e8aecace' 
  AND token = 'OnZ9bSr7jj+2nOY3f7WsTHtuxcOXoHxf3R/rkmJesxY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00055

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}