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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b2a78e8d650535417a572a6d5c6f750650ecfb3f90f3ead6c4e04b99d373f7cc' 
  AND token = 'Io3qTlA2OA6mYyZzsdvSR4L2fnTdeARRgBA2dy9kWM0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}