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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b343ef46f6af868985e6a53d22aa1e1f4451511e42259638252712b0e8ba3a45' 
  AND token = 'zRBjTG2nzZ3sMSlDiBU9/YCU9xouE2DSyZpEEZlcEq8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}