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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd449b863bca131dce5ffe9ba52050f0d474fda43c18e948ac641b6d8c04676f8' 
  AND token = 'VBUkRzF2w0WVrRLJCZkfzzQTR4sxq0ufBAp7FzSYtt4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}