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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1f67346c3345c40f5d56dd19d59f8ec1ba3d0641999222db043bf64162cdd05b' 
  AND token = 'Av0Rip3dYHpjyatV8tR3KwZiMfJVFOLtbpBWSk9lnPQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}