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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '41a9d8e70cb508bb3fb2e2972040fda24725ec56f98fa9d68c8d45d03d2d6f79' 
  AND token = '46QWpUMI9PgwsBx1ZV8MQPHtX9cQs2BR0X7lPYzrtX0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}