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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'afe08a880cd945e28b370240e75c3d46449d5ebeadf0a62f6630a5026bcb7b21' 
  AND token = '8mFEliC87f924fNulurWPyuGa0i+JSin1GUoqohk7kM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}